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Philosophy of Mind & Neuroscience
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John Bickle: Unnoticed Features of Exploratory Experiments from the 60-Year History of the N-methyl – D-aspartate (NMDA) Receptor
John Bickle: Unnoticed Features of Exploratory Experiments from the 60-Year History of the N-methyl – D-aspartate (NMDA) Receptor
Abstract: The structure, function and activities of the N-methyl-D-aspartate receptor (NMDAR) now stand among neurobiology’s greatest discoveries. This history is fascinating in and of itself. It spanned more than sixty years, from initial investigations in the late-1950s into glutamate as a purported neurotransmitter, to successes less than a decade ago in finally getting X-ray-crystallographic [...]